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Infectio

Print version ISSN 0123-9392

Abstract

MARQUEZ-HERRERA, Kelly; ROJAS-VEGA, Alejandra  and  CAMACHO-MORENO, Germán. Characterisation of patients with carbapenemase- producing Klebsiella isolates in a third-level paediatric hospital in Bogota, Colombia. Infect. [online]. 2016, vol.20, n.4, pp.231-237. ISSN 0123-9392.  https://doi.org/10.1016/j.infect.2015.11.001.

Objective:

To describe the clinical characteristics of paediatric patients with carbapenemase-producing Klebsiella isolates.

Material and methods:

Between 2012 and 2015, we conducted a descriptive study that included patients aged 0-18 years (mean 4.8 years), all with Klebsiella carbapenemase-producing isolates.

Results:

The infection was documented in 21 patients, 81% of the patients had a history of hospitalisation in the last 6 months and 67% had undergone antibiotic therapy. The isolation sites were blood (48%), urine (33%), pleural fluid (9%), peritoneal liquid and trachea (5). Ninety-five percent of the patients had associated comorbidity; 81% of the isolates corresponded to nosocomial infections. The hospital departments were the paediatric intensive care unit (43%), general paediatrics (29%), oncology, neonatal unit and emergency department (9.5% each). Eighty-one percent of the isolates had co-resistance to other antimicrobials. Definitive treatment was performed with monotherapy in 19% of the cases, double therapy in 28.5% and triple therapy in 23.8%. The mortality rate was 24%.

Keywords : Klebsiella; Carbapenemase; Paediatrics.

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