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SANCHEZ, Liliana; MATTAR, Salim  and  CONTRERAS, Verónica. First case of haemophagocytic syndrome associated to probable infection with Rickettsia of spotted fever group, Meta, Colombia. Infect. [online]. 2017, vol.21, n.3, pp.192-194. ISSN 0123-9392.

This study describes a case of hemophagocytic syndrome (SHF) probably associated with infection by a species of Rickettsia spotted fever group (SFG). The patient was an eight years old girl from a rural tropical area of Meta department, in eastern of Colombia, which was admitted to the Hospital of Villavicencio with high fever three days of evolution, headache, rash, asthenia, abdominal pain, lymphadenopathy and hepato-splenomegaly. Serological analyses for HIV, hepatitis, cytomega- lovirus, Epstein Barr virus, and other were negatives. The patient was admitted in undifferentiated tropical fevers and paired serum samples were analyzed through the indirect immunofluorescence assay (IFI) to detect antibodies IgG against Rickettsia of SFG. Antibodies titles in acute phase (IgG 1:64) and convalescent phase (IgG 1:1024) demonstrated seroconvertion. Because the rapid remission of clinical manifestations after treatment with doxiciclina, the cause of hematophagocitic syndrome was attributed to the infection by rickettsia of SFG.

Keywords : Rickettsia; spotted fever; infection; phagocytosis.

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