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Print version ISSN 0123-9392


HIGUITA-GUTIERREZ, Luis Felipe  and  JIMENEZ-QUICENO, Judy Natalia. Outbreaks of colistin resistant bacteria: systematic review. Infect. [online]. 2017, vol.21, n.4, pp.214-222. ISSN 0123-9392.


Colistin has become a drug commonly used in endemic countries in resistance to carbapenems; however, with their use has emerged the resistance. The objective: of this study is to describe outbreaks by bacteria resistant to colistin


Systematic review of the literature in five databases with the criteria guide PRISMA of identification, tamization, election and inclusion.


13 outbreaks were identified in 7 different countries, 77% (n = 10) in Italy and Greece, and 61.5% (n = 8) in K. pneumoniae strains. Patients had baseline conditions, multiple comorbidities and frequent exposure to health services. Tests and susceptibility criteria were variable, the resistance mechanisms that are simultaneously with the resistant to colistin include carbapenemases and extended spectrum beta-lactamases. The predominant genotype according to MLST was the ST-258.


The emergence of resistance to colistin is not limited to an age group or a specific comorbidity; however, it concentrated in countries where resistance to carbapenems is endemic. This allows alert health authorities and hospitals to establish programs of surveillance, prevention and control that enable timely detection and containment of this problem

Keywords : Disease Outbreaks; colistin; Drug Resistance.

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