SciELO - Scientific Electronic Library Online

vol.23 suppl.1Identification of mutations associated with resistance to Integrase Strand Transfer Inhibitors (INSTI) in ART-naïve HIV- 1 patients in Medellin, Colombia author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google



Print version ISSN 0123-9392


GUALTERO, Sandra et al. Integrase Strand Transfer Inhibitors: Bases for its use in the clinical practice. Infect. [online]. 2019, vol.23, suppl.1, pp.106-128. ISSN 0123-9392.

Integrase strand transfer inhibitors (INSTI) are drugs whose mechanism of action consists of blocking the integration process of the proviral DNA to the host DNA by binding to the catalytic site of the viral integration and thus preventing its replication. Currently it has the approval of INSTI of first generation, two of second generation and in process of approval of a third of second generation. The two generations has similitude in its mechanisms of action, changes in its structures that modify its genetic barrier, but keeping his security and effectiveness profile. Since the approval of INSTI´s in 2007 to date, multiple clinical studies have been carried out, whose results have allowed us to advance in the knowledge of their effectiveness in different clinical scenarios; (naive patients, experienced patients, simplification and prophylaxis schemes, as well as in the knowledge of their profile of resistance mutations). In the present article, we made a review of the members of this family of antiretrovirals (ARV).

Keywords : integrase inhibitors; antiretrovirals Integrase Inhibitors; HIV; Treatment Outcome; Drug Resistance.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )