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Print version ISSN 0123-9392


VELEZ-PAEZ, Jorge Luis et al. Mean platelet volume as a predictor of mortality in patients with sepsis: systematic review and meta-analysis. Infect. [online]. 2020, vol.24, n.3, pp.162-168. ISSN 0123-9392.


Platelet mean volume (MVP) is a biomarker used in the integral approach to sepsis.


To assess the association between MVP and mortality in patients with sepsis.


A systematic review of observational studies in five databases was performed. Mortality associated with sepsis was analysed; interventions considered were MPV, APACHE and serum lactate.


Regarding mortality associated with sepsis, a significant value was found in the MVP at 72 hours (200 deceased versus 654 not deceased; MD 0.83 IC95% 0.53-1.13, p=<0.0001, I2 =72.9%); as well as the value of APACHE II (220 dead versus 604 not deceased; MD 0.81 IC95% 0.62-1.0, p= 0.0001, I2 =32%). No statistical significance was found for the other clinical variables.


Increased MVP is associated with increased risk of mortality in patients with sepsis, especially after 72 hours of evolution of clinical features.

Keywords : Mean Platelet Volume; Sepsis; Mortality; Systematic Review.

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