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Print version ISSN 0123-9392


ANGLES-YANQUI, Eddie; CHUMBES-PEREZ, Jorge  and  HUARINGA-MARCELO, Jorge. Colistin-based treatment for extensively drug resistant (XDR) Pseudomonas aeruginosa and Acinetobacter baumannii infection at a third level hospital. Infect. [online]. 2020, vol.24, n.4, pp.201-207. ISSN 0123-9392.


To describe the clinical response and overall mortality of Colistin in infections by Pseudomonas XDR and Acinetobacter XDR at the Hospital Nacional Arzobispo Loayza in Lima, Peru.


Observational, descriptive, retrospective study. Records of all patients > 18 years old, from June 2014 to June 2016, who had infection by Pseudomonas XDR or Acinetobacter XDR confirmed by culture, and who received colistin, were included. A univariate analysis of the general characteristics of the patients was performed; a bivariate analysis with a Chi2, t-student or ANOVA test as appropriate, and the factors associated with mortality were also determined.


56 patient records were included; the median age was 46,5 [31,5 to 63,5]. The Culture was positive for Pseudomonas XDR in 48,2% and for Acinetobacter XDR in 51,8%. The favorable clinical response was 85,7% at 15 days and 78,6% at 30 days. In-hospital mortality at 30 days was 21,4%, ICU mortality was 30,8% and nephrotoxicity was 5,4%.


Colistin combined with another antimicrobial had a favorable clinical response in infection with Pseudomonas XDR and Acinetobacter XDR.

Keywords : Colistin; Acinetobacter; Pseudomonas aeruginosa; gram-Negative Bacteria.

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