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Print version ISSN 0123-9392


BARBOZA, Joshuan J. et al. Kawasaki disease, Kawasaki-like disease, and MIS-C associated with COVID-19 in children: systematic review. Infect. [online]. 2022, vol.26, n.2, pp.137-144.  Epub Dec 12, 2021. ISSN 0123-9392.


To synthesize the epidemiological and clinical characteristics of COVID-19 children with MIS-C, KLD and EK.


Databases and preprints were searched until May 31, 2021. Reports/case series that evaluated the clinical features of EK, KLD, or MIS-C in pediatric patients with COVID-19 were included.


Sixteen studies were included (six case reports and ten case series, 367 patients total, 58 patients with EK, 87 with KLD, and 290 patients with MIS-C); with ages ranging from 6 months to 10 years, and 62% were female. Positive COVID-19 was observed in 75.2%. Regarding EK, KLD and MIS-C, the reported clinical characteristics were compatible with the standardized diagnostic pictures in the context of COVID-19. The duration of hospitalization was 5 to 14 days for EK and 4.3 to 13 for MIS-C. Eleven patients with MIS-C (2.8%) needed ECMO. Eleven patients with MIS-C (2.8%) needed ECMO. Six patients with MIS-C were reported dead. Eight studies reported patients in the ICU.


Children with COVID-19 develop EK or KLD, and can be complicated by MIS-C. Prevention, diagnosis, and treatment measures are needed.

Keywords : Kawasaki diseases; Multisystemic inflammatory syndrome; COVID-19.

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