Abstract

GAITAN DUARTE, Hernando; RUBIO ROMERO, Jorge A.  and  ESLAVA SCHMALBACH, Javier. Association between the cervico-vaginal inflammatory citology and the intraepithelial cervical lesion in patients from a Sexual and Reproductive Health Clinic in Bogotá, Colombia, 1999-2003 . Rev. salud pública [online]. 2004, vol.6, n.3, pp.253-269. ISSN 0124-0064.

OBJECTIVES: Cervical cancer is the most common malignancy affecting Colombian women. Pap smear screening is used for its early detection. Early stages of cervical cancer can be expressed by the presence of inflammatory atypia in the Pap smear. The main objective of this study is to evaluate the role of inflammatory atypia in Pap smear as a marker of squamous intraepithelial lesions (SIL), given that it is not clear how to deal with the presence of inflammatory cells in Pap smear. MATERIALS AND METHODS: A cross sectional study was carried out to establish the operative characteristics of the cervical Pap smear in the colposcopy clinic of the Clínica Piloto Profamilia, Bogotá, between January 1999 and December 2003. We compared patients with biopsies reporting SIL and those with a benign report in the pathologic study. We evaluated sensitivity the and the specificity of the Pap smear in different cutting points compared to the pathology report as gold standard. RESULTS: The prevalence found was 48,7 % for low grade - Squamous Intrepithelial Lesions (SIL) and 9,7 % for high grade - SIL. The best performance for the Pap smear test to detect SIL was when the atypical squamous cells of undetermined significance (ASCUS) were considered as abnormal. Severe inflammatory atypia were associated to SIL in a similar way as to ASCUS. CONCLUSIONS: Sensitivity of the Pap smear as a screening test decreases when excluding Pap smears reporting ASCUS as a cutting point. In our environment, we recommend to report inflammatory atypia on the Pap smear test stratified by severity until the role of severe inflammatory atypia for the diagnosis of SIL is defined.

Keywords : Diagnosis; vaginal smear; cervical intraepithelial neoplasia; screening.

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