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Revista de Salud Pública

Print version ISSN 0124-0064

Abstract

GARCIA-MOLINA, Mario et al. Cost-effectiveness of risk stratification tests for the treatment of acute myeloid leukemia in pediatric patients. Rev. salud pública [online]. 2017, vol.19, n.5, pp.657-663. ISSN 0124-0064.  http://dx.doi.org/10.15446/rsap.v19n5.56508.

Objective

To estimate the cost-effectiveness of risk-stratification tests for the treatment of acute myeloid leukemia (AML) in pediatric patients.

Methods

A decision-tree model was built using Life Years Gained as a measure of effectiveness. Costs were estimated considering the perspective of the Colombian health system. Stratification costs included treatment costs based on said stratification. Drug prices were taken from SISMED (Drug Price Information System) 2008 and the monetary value of the procedures was extracted from the ISS 2001 rate manual, plus 30%. All costs were expressed in Colombian pesos for 2010 and the gross domestic product per capita of the same year was used as a cost-effective threshold. Univariate and probabilistic sensitivity analyzes were performed.

Results

Risk stratification tests have an incremental cost-effectiveness ratio of COP 8,559,944. These results are sensitive to changes in probabilities of relapse, transplant survival and side effects.

Conclusion

Risk stratification tests for AML treatment in pediatric patients are cost-effective in the context of the Colombian health care system.

Keywords : Cost-Effectiveness analysis; acute myeloid leukemia; risk assessment; stem cell transplantation; consolidation chemotherapy (source: MeSH, NLM).

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