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Revista de Salud Pública

Print version ISSN 0124-0064


MURILLO-ZAMORA, Efrén et al. Clinical markers associated with acute laboratory-confirmed Dengue infection: results of a national epidemiological surveillance system. Rev. salud pública [online]. 2017, vol.19, n.6, pp.744-748. ISSN 0124-0064.


To evaluate the association of several clinical markers with acute laboratory-positive Dengue Virus infection.


A hospital-based case-control study was conducted in the state of Colima, Mexico, by using information from the National System of Epidemiological Surveillance (Sistema Nacional de Vigilancia Epidemiológica [SINAVE]) for Dengue. Data from 2 732 cases and 2 775 frequency-matched controls were analyzed. Odds Ratio (OR) and the 95 % Confidence Interval (CI), estimated by means of logistic regression models, were used.


The presence of skin rash (OR=1,7; 95 % CI 1,5-2,1), persisting vomiting (OR=1,8; 95 % CI 1,5-2,3) and increased capillary fragility (petechiae, ecchymosis, hematoma or positive tourniquet test; OR=1,8; 95 % CI 1,2-2,6) were associated with laboratory-positive infection.


Three clinical markers were significantly associated with an increased risk of acute laboratory-confirmed dengue infection. These findings would support accurate and timely diagnosis of dengue in laboratory-limited settings.

Keywords : Dengue; epidemiology; population surveillance; communicable diseases; case-control studies (source: MeSH, NLM).

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