Objective

To assess lipid peroxidation in pubescent adolescents with excess weight and the presence or absence of insulin resistance.

Materials and Methods

This was a descriptive, correlational and cross-sectional study carried out in 80 adolescents aged between 12 and 15 years. Lipid profile, oxidized LDL, 8-Isoprostane and LDL oxidation rates were estimated. BMI was determined and waist circumference was measured.

Results

Overweight and insulin resistance adolescents showed a oxidized LDL, 8-iso-prostane and oxidized LDL-C/HDL ratio higher than those who were overweight without insulin resistance and that the control group (p<0.05).

Conclusion

Adolescents with excess weight and insulin resistance showed higher concentrations of lipid peroxidation markers than the rest of the adolescents evaluated, which may imply a possible role of oxidative stress in the development of insulin resistance. These results highlight the importance of promoting good nutrition and healthy lifestyles to prevent these adolescents from becoming obese adults with associated comorbidities, affecting their quality of life and life expectancy.