Abstract

VELASCO BENITEZ, Carlos Alberto; LADINO MELENDEZ, Liliana  and  LUNA MEDICIS, Ángela Patricia. Effect of parenteral nutrition intravenous lipids on platelet blood counting in term and preterm newborns. Perspect Nut Hum [online]. 2010, vol.12, n.1, pp.25-32. ISSN 0124-4108.

Introduction: Parenteral nutrition (NPT) support is another option in newborn when they cannot receive enteral nutrition. Thrombocytopenia has been reported as a complication for the use of NPT intravenous lipids. Objective: To evaluate the effect of NPT intravenous lipids on platelet blood counting in newborns. Materials and methods: this is a prospective study carried out in newborns requiring parenteral nutrition support who were hospitalized in Bucaramanga- Colombia. All patients received intravenous lipids. Doses were increasing of 0,5 g/kg/ day at the first day to reach 3 g/kg/day at the end. They were monitored daily and platelet blood counting was assessed at baseline and seven days later. Results: subjects were 22 term newborns and 29 preterm (55% men), they presenting different clinical conditions like prematurity (22), necrotic enterocolitis (17), respiratory problems (4), esophageal atresia (2) and others (6). The platelet blood counting showed no significant differences between baseline and the seventh day (p> 0.05), no in preterm (227.320±86290/mm³ versus 294.930±120.600/mm³),and either in the newborns (276.140±130.240/mm³ versus 273.240±96.890/mm³) no adverse effects were reported. Conclusion: administration of intravenous lipid at doses up to 3 g/ kg / day in term and preterm newborns is safe, and no thrombocytopenia was not reported and other adverse effects.

Keywords : parenteral nutrition; fat emulsions intravenous; thrombocytopenia; platelet count; infant newborn.

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