Abstract

PENA, Julio Alejandro et al. Associated complications and survival analysis in children with acute leukemia treated with BFM-95 protocol. Univ. Salud [online]. 2014, vol.16, n.1, pp.7-19. ISSN 0124-7107.

Objective: To determine complications and survival percentage in children suffering from acute lymphoid and myeloid leukemia treated with Berlin-Frankfurt-Münster 95 (BFM-95) protocol from January 2008 to December 2010 at Los Ángeles Children Hospital. Materials and methods: A retrospective cohort was designed to evaluate children treated with BFM-95 protocol during three years at Los Ángeles Children Hospital. The Information was obtained from the patient demographics, complications associated with BFM-95 protocol and survival. Data were collected from medical records and hospital decease reports. Nominal variables were presented as proportions and the continuous variables were presented as means and standard deviations. The survival analysis was performed using Kaplan-Meier method. Data were analyzed using the Statistical Package for Social Sciences, 17.0 version software (SPSS Inc., Chicago, Illinois, USA). Results: Fifty two children were included in this study. From the whole group, 47 (90.4%) had acute lymphoid leukemia and 5 (9.6%) had acute myeloid leukemia. Thirty five (67.3%) presented complications. Twenty three children (65.7%) had infectious complications, being the most frequent ones. Kaplan-Meier survival analysis showed that patients with complications have shorter survival time compared to patients with no complications. Conclusions: The incidence of complications was high in children treated with BFM-95 protocol. Kaplan-Meier analysis revealed differences between acute lymphoid leukemia and acute myeloid leukemia according to complications.

Keywords : Acute lymphoid leukemia; acute myeloid leukemia; child; complications; survival analysis; epidemiology.

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