Resumo

GUERRERO-GOMEZ, Oliva Alexandra  e  GUERRERO-FLOREZ, Milena. MicroRNAs associated with Cervical Cancer and its precursor lesions: A systematic review. Univ. Salud [online]. 2016, vol.18, n.2, pp.345-363. ISSN 0124-7107.

Introduction: MicroRNAs (miRNAs) have special interest in oncology because of its role in the control of the expression of cell cycle regulatory genes, gene alterations and its involvement on different types of cancer such as cervical cancer (CC). Materials and methods: A systematic literature search was performed using different databases to establish relationship of miRNAs with UCC. Genomic and chromosomic location of miRNAs were analyzed along with its functional classification, miRNAs groups they belong to, and possible roles in progression of the disease. Results: 139 scientific articles about the role of miRNAs in CC were included. A total of 272 miRNA were identified, from which 252 had differential expression in cervical cancer tissue: 97 miRNAs were overexpressed, 88 miRNA infra-expressed and 67 miRNAs with variable expression profile. The majority of miRNAs associated with CC were found in chromosome 1, 14, 19 y X, and in intronic and intergenic regions. MiRNAs associated with process of cell cycle control were identified. Conclusion: This review emphasizes the importance of miRNAs as potential biomarkers of prognosis and diagnosis; it also provides an update on miRNAs associated to CC and its precursor lesions and a resource of compilation and consultation valuable to guide future research in molecular medicine in this field is generated. However, there is need to develop more studies in order to clear the mechanisms of miRNAs in cervical cancer.

Palavras-chave : Cervical cancer; microRNAs; biomarkers; diagnosis; molecular biology.

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