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Universidad y Salud

Print version ISSN 0124-7107On-line version ISSN 2389-7066


RODRIGUEZ-VELASQUEZ, Javier; PRIETO, Signed  and  RAMIREZ-LOPEZ, Leonardo. Adult dynamic heart evaluated by the proportions of entropy. Univ. Salud [online]. 2017, vol.19, n.2, pp.248-257. ISSN 0124-7107.


A new mathematical methodology of clinical application has been developed from the theory of dynamic systems, together with the theory of probability and the concept of entropy.


To apply the methodology previously developed to evaluate the heart dynamics of adult through the probability and proportions of entropy of the attractor.

Materials and methods:

A blind study was developed taking as Gold Standard the conventional diagnosis issued by an expert with 480 Holter, 30 normal dynamics and 450 with different pathologies. For each Holter, a numerical attractor was generated by quantifying the probability of appearance of consecutive pairs of cardiac frequencies, subsequently evaluating entropy, S/K ratio and proportions for each dynamic for at least 18 hours. The values of sensitivity, specificity and Kappa coefficient were found.


The applied methodology allowed to differentiate quantitatively normality of disease, finding the values of the proportions in the established ranges. The sensitivity and specificity values were 100%, and Kappa coefficient was 1.


It is possible to diagnose cardiac dynamics for at least 18 hours based on the probability distributions of the appearance of consecutive pairs of cardiac frequencies and their entropy.

Keywords : Ambulatory electrocardiography; mathematics; nonlinear dynamics; heart rate.

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