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Universidad y Salud

versión impresa ISSN 0124-7107
versión On-line ISSN 2389-7066


QUENAN, Yoccner Edilson  y  OSORIO, José Henry. Relationship between obesity, adipocytokines and osteoarthritis: Review. Univ. Salud [online]. 2017, vol.19, n.3, pp.410-418. ISSN 0124-7107.


Some adipocytokines expressed by osteoblasts, chondrocytes and synoviocytes are responsible of the inflammation and degradation of the extracellular matrix in the joints, which generates osteoarthritis.


To review the current state of knowledge around the relationship between obesity, adipocytokines and osteoarthritis.

Materials and methods:

An electronic search was carried out in the databases of BBCS-LILACS, PubMed, IB-PsycINFO, IB-SSCI, IB-SciELO, Scopus and Science Direct in English and Spanish, without limiting the search by date. Clinical trials, meta-analyses, reviews, case reports and classic articles related to obesity and its implications were included as well as osteoarthritis, adipocytokines, adipose tissue and joint inflammation.


822 articles were found; however, 78 documents met the selection criteria for the relevance of the information. This work was divided into three sections: Osteoarthritis and obesity, osteoarthritis and inflammation and osteoarthritis and adipocytokines.


Nowadays, obesity is associated with the development of osteoarthritis, as it triggers a series of inflammatory processes mediated by the adipocytokines. Several studies recommend the development of clinical research to understand the behavior of adipocytokines before and during the development of osteoarthritis.

Palabras clave : obesity; inflammation; metabolism; adipose tissue; osteoarthritis.

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