Abstract

MACHADO-ALBA, Jorge E.  and  GIRALDO-GIRALDO, Claudia. RISK IDENTIFICATION OF TOXICITY AND OTHER PROBLEMS RELATED TO DRUGS IN PATIENTS AFFILIATED TO A HEALTH SYSTEM. Investig. andina [online]. 2010, vol.12, n.20, pp.19-28. ISSN 0124-8146.

Objectives: to identify possible pharmacological interactions that could be related with probable negative results associated with medications, by means of searching active data bases of patients affiliated to a health system. Methods: by reviewing statistics of medicines known to present risk interactions throughout systematic data bases of medication providers, in about 4.5 million users in Colombia. Results: the findings reveal cases ofsimultaneous use of three phosphodiesterase-5 enzyme inhibitors, antagonism between levomepromazine and cabergoline; use of 2 proton pump inhibitors and sucralfate at the same time; irregular dispensation of antiretroviral agents, non-indicated use of somatropine and simultaneous use in the central nervous system of stimulating and depressive drugs. Conclusions: the active search allows optimizing resources, to prevent adverse events that can potentially cause morbidity, or to determine problems that could be responsible for the therapeutic failure, anticipating the appearance ofprobable risks to the patient.

Keywords : adverse drug reaction; pharmacoepidemiology; health services; surveillance of marketed products.

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