Abstract

ISAZA, Carlos; HENAO, Julieta  and  BELTRAN, Leonardo. RESISTANCE AND SENSIBILITY TO WARFARINA. Investig. andina [online]. 2010, vol.12, n.20, pp.30-40. ISSN 0124-8146.

Warfarin is the most prescribed oral anticoagulant in the world. The handling of this drug is difficult due to it's narrow therapeutic range, wide variety of interactions, and great inter-individual variability in the response. In a cohort of 145 patients prescribed with warfarin, a series of cases of susceptibility (dose≤15 mg/ week) and resistance (doses≥70 mg/week) are reported here. After a brief review of relevant pharmacological aspects, we discuss the possible factors causing these exaggerated responses to the drug.

Keywords : warfarin; pharmacogenetics; CYP2C9; VKORC1; CYP4F2.

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