Introduction.

In Medellin, Colombia, the prevalence of the seven transmissible infections in blood banks is unknown.

Materials and methods.

Cross-sectional study with 25 842 donors. High validity detection Tests were applied. Frequencies with their confidence intervals of 95% were estimated. The associated factors were identified through Chi square of Person, Fisher's exact Test, crude odds ratios and adjusted by logistic regression.

Results.

The global reactivity was 3.3% in 2015 and 3.5% in 2016; hepatitis B virus 1.6%, HCV 0.4%, HTLV 0.2%, T Pallidum 1.1% and T. Cruzi 0.1%. The global reactivity and Viral infections were statistically higher in men, older donors of age, housewives, non-repetitive and first-time donors.

Conclusion.

It was found a high frequency of infections that imply great economics losses for the bank and the need to improve selection processes. The identification of groups with higher prevalence allows to focus educational and investigative efforts.

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