Abstract

RUBIO-VARGAS, Catalina; ALCAZAR, Jessica  and  FRANCIS-TURNER, Liliana. Influence of fibroblast growth factor 2 on stem cells in vitro. Review. Actu Biol [online]. 2019, vol.41, n.111, pp.45-52. ISSN 0304-3584.  https://doi.org/10.17533/udea.acbi.v41n111a03.

The interest and need to study stem cells in regenerative therapies has increased in recent years due to their ability to proliferate and differentiate into multiple lineages. Unfortunately, the number of cells needed for a successful transplant is greater than that obtained directly from the patient, so in vitro cultures of stem cells must be done. However, over time the cells in these cultures become senescent, decreasing their number of cellular divisions and their proliferative capacity. To solve this problem, different growth factors have been proposed as promoting agents for cell proliferation. Among these is the fibroblast growth factor 2 which, when added to the medium, could promote proliferation and increase the life time of the cells in the culture. The following review compiles information about the biology of this growth factor and the type of signaling it uses, as well as its applications in regenerative therapy and its effect on cell proliferation and senescence.

Keywords : FGF-2; cell proliferation; senescence; cellular therapy.

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