Abstract

QUIROGA PUELLO, Jairo. 5-Aminopyrazoles as a building block for fused heterocyclic compounds. Rev. acad. colomb. cienc. exact. fis. nat. [online]. 2019, vol.43, n.168, pp.531-538. ISSN 0370-3908.  https://doi.org/10.18257/raccefyn.762.

Heterocyclic compounds have an important place among the large groups or families of compounds that make up organic chemistry. This is not only due to its structural diversity and chemical properties, which makes them attractive as synthetic auxiliaries, but also because their heterocyclic nuclei are constituents of natural products and play a key role in biological processes. Their application as therapeutic agents for the treatment of various diseases also turns their structural units in targets of medicinal chemistry. This study is a summary of the research conducted by the author and his group on the subject of aminopyrazoles and their importance in the synthesis of heterocyclic compounds of greater complexity. The design, synthesis, and study of new compounds containing the pyrazole nucleus have been carried out in the Heterocyclic Compounds Research Group (GICH) of the Chemistry Department at Valle University where together with other national and international institutions, we have studied the possible antitumor, antifungal, and antibacterial activity of some of the new compounds.

Keywords : Hydrazines; Nitriles; Aminopyrazole; Bielectrophiles; Methylene active compounds; Pyrazolopyridine; Pyrazolopyrimidine.

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