Abstract

RAMIREZ GUERSON, Giovanni Aleksey; LINARES MARQUEZ, Pascual  and  PASCUAL MATHEY, Luz Irene. Bioethical perspective for Mexico, Spain, and the United States in in-vivo models of DNA damage induction. rev.latinoam.bioet. [online]. 2022, vol.22, n.2, pp.51-64.  Epub Dec 31, 2022. ISSN 1657-4702.  https://doi.org/10.18359/rlbi.5592.

Currently, biomedical research has focused on the study of diseases such as cancer that causes a high mortality rate. Different animal models are used to generate different types of carcinogenesis; direct DNA damage is one of the most used mechanisms. However, current national and international regulations do not indicate the bioethical aspects that must be followed to develop an experimental model of DNA damage. In addition, they do not perform a correct resemblance of the disease. Due to the above, this review analyzes the advances in regulations generated in different countries, comparing the studies found in the United States, Mexico, and Spain. The future perspective is to be able to count on updated experimentation guidelines, which allow the establishment of the necessary norms for the adequate development of animal research models of DNA damage that comply with the 3R rule in animal experimentation. This initiative should be carried out jointly by the World Health Organization and organizations specialized in managing and caring laboratory animals at the national and international levels.

Keywords : in vivo models; DNA damage; animal models; bioethics; standards; safety.

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