Abstract

LAMPREA, Marisol R  and  URUENA-MENDEZ, Ginna Paola. Systemic Inactivation of GR and MR Receptors on Corticosterone-induced rapid damage in Spatial Memory Recovery. Univ. Psychol. [online]. 2016, vol.15, n.spe5, pp.1-11. ISSN 1657-9267.  https://doi.org/10.11144/Javeriana.upsy15-5.eisr.

Previous studies of our laboratory have shown that it is difficult to recover the spatial memory in the Barnes maze ten minutes after a systemic administration of corticosterone; however the mechanisms that underlie this effect are unknown. Considering glucocorticoids exert their actions through GR and MR type receptors, the present study evaluated the participation of these receptors in the rapid damaging effect of corticosterone on spatial memory. For this, 37 male Wistar rats were trained on the task and 24 h afterwards they received a subcutaneous injection of GR antagonist, MR antagonist or vehicle. 50 min later the animals were injected with corticosterone or vehicle intraperitoneally and 10 min later, the spatial memory recovery was evaluated. The results indicated that corticosterone rapidly impaired spatial long-term memory recovery, as animals injected with this hormone presented higher escape latencies, more errors, higher exploration and greater traveled distance to reach the goal; an effect reverted only with the administration of the MR antagonist. This finding agrees with in vitro studies showing that the rapid effects of corticosterone on glutamatergic transmission in the hippocampus are mediated by MR receptors.

Keywords : corticosterone; rapid deficit in recovery; spatial memory; Barnes maze; glucocorticoid receptors.

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