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Colombia Médica

versão On-line ISSN 1657-9534


CASTILLO, Germán Gabriel et al. Study of the gastric acid anti-secretory activity of Cannabis sativa in an animal model. Colomb. Med. [online]. 2006, vol.37, n.4, pp.254-257. ISSN 1657-9534.

Introduction: There are few studies that describe the effects of cannabinoids in the gastric system, although in only one, there was the description of a gastric pH alteration. Objective: To determine the anti-secretory effect of the species Cannabis sativa. Methodology: In this study forty five Sprague Dawley rats were used, they were submitted to a 24 hours fasting period, after which the pylorus was ligated for 2-4 hours, according to the experimental group. Thereafter, the rats were anesthetized, their stomachs extirpated and the gastric content analyzed for volume and pH. Results: The Cannabis extract raised the gastric pH when compared to the control group (p <0.05), with no significant differences found between the reference drug (ranitidine) and the Cannabis extract (p >0.05). There were no differences in the measured volumes. Conclusions: These results suggest that the Cannabis sativa extract diminishes the gastric acid output.

Palavras-chave : Cannabis; Gastric juice; Cannabinoids; Tetrahydrocannabinol.

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