Resumo

CASTILLO, Andrés. HPV infection and carcinogenesis in the upper aero-digestive tract. Colomb. Med. [online]. 2011, vol.42, n.2, pp.233-242. ISSN 1657-9534.

Recently, molecular and epidemiological studies have shown an etiologic role for human papillomavirus (HPV) in a subset of upper aero-digestive tract (UADT) cancers in women and men. Oral HPV infections acquired through oral sex seems to be the main risk factor for HPV-associated oral cancers. The high-risk type HPV-16 was the most prevalent infection HPV-positive in most oral cancers. Therefore, the prophylactic vaccine against HPV-16 could prevent HPV associated oral cancer if the vaccine were demonstrated to be capable of preventing oral HPV-16 infection. Thus, these findings have created new potential opportunities for the primary prevention of oral cancers.

Palavras-chave : Human papillomavirus; Carcinogenesis; Squamous cell carcinomas; The upper aero-digestive tract.

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