Serviços Personalizados
Journal
Artigo
Indicadores
- Citado por SciELO
- Acessos
Links relacionados
- Citado por Google
- Similares em SciELO
- Similares em Google
Compartilhar
Colombia Médica
versão On-line ISSN 1657-9534
Resumo
CESPEDES, Nora; VALLEJO, Andrés; AREVALO-HERRERA, Myriam e HERRERA, Sócrates. Malaria vaccines: high-throughput tools for antigens discovery with potential for their development. Colomb. Med. [online]. 2013, vol.44, n.2, pp.121-128. ISSN 1657-9534.
Malaria is a disease induced by parasites of the Plasmodium genus, which are transmitted by Anopheles mosquitoes and represents a great socio-economic burden Worldwide. Plasmodium vivax is the second species of malaria Worldwide, but it is the most prevalent in Latin America and other regions of the planet. It is currently considered that vaccines represent a cost-effective strategy for controlling transmissible diseases and could complement other malaria control measures; however, the chemical and immunological complexity of the parasite has hindered development of effective vaccines. Recent availability of several genomes of Plasmodium species, as well as bioinformatic tools are allowing the selection of large numbers of proteins and analysis of their immune potential. Herein, we review recently developed strategies for discovery of novel antigens with potential for malaria vaccine development.
Palavras-chave : Malaria; vaccines; Plasmodium; Antigens; peptides; Recombinant Proteins.