SciELO - Scientific Electronic Library Online

 
vol.47 issue3Health care utilization of mexican patients with medically unexplained physical symptomsStrength and ability to implement the activities of daily living in elderly resident in rural areas author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Colombia Médica

On-line version ISSN 1657-9534

Abstract

RESTREPO VALENCIA, César Augusto  and  AGUIRRE ARANGO, José Vicente. Vitamin D (25(OH)D) in patients with chronic kidney disease stages 2-5. Colomb. Med. [online]. 2016, vol.47, n.3, pp.160-166. ISSN 1657-9534.

Objective:

To establish the impact the chronic kidney disease stage has in the native vitamin D levels in patients not undergoing dialysis treatment.

Methods:

A study performed in Manizales, Colombia, a city located 2,200 meters above sea level, without important stational variations. Patients with 18 years of age or more, with chronic kidney disease stages 2 to 5 and not undergoing dialysis treatment were recruited for this study. Demographic and anthropometric variations were evaluated as well as solar exposure, CKD etiology and laboratory variables related to bone and mineral diseases. For each CKD clinical stage, correlations were evaluated for vitamin D levels, laboratory results for bone and mineral diseases, solar exposure and ethnicity.

Results:

Three hundred thirty-three patients were evaluated with a median age of 71 years, most of them mestizo (71%), 173 were women. The main CKD etiology was hypertensive nephropathy (32.2%). 21.1% of patients had normal vitamin D levels, 70.1% were within insufficient range and 8.8% were in deficit. A negative correlation was found between the levels of vitamin 25 (OH) D and the values for: creatinine, phosphorous, calcium x phosphorous product, PTH, 24 hours urine protein and BMI. A positive relationship was found for calcium and albumin. Positive significant statistical correlation was found for vitamin 25(OH) D levels and solar exposure for stages 3b and 4 of CKD.

Conclusions:

It is common to find low levels of vitamin 25(OH) D in patients with CKD; these can contribute to the appearance of secondary hyperparathyroidism.

Keywords : Kidney failure; chronic; vitamin D deficiency; hyperparathyroidism calcitriol; ergocalciferols; skin pigmentation; renal insufficiency.

        · abstract in Spanish     · text in English | Spanish     · English ( pdf ) | Spanish ( pdf )