Abstract

CHUAIRE NOACK, Lilian. New clues to understand gastroschisis. Embryology, pathogenesis and epidemiology. Colomb. Med. [online]. 2021, vol.52, n.3, e4004227.  Epub Sep 30, 2021. ISSN 1657-9534.  https://doi.org/10.25100/cm.v52i3.4227.

gastroschisis is a congenital structural defect of the abdominal wall, most often to the right of the umbilicus, through which the abdominal viscera protrude. Its developmental, etiological and epidemiological aspects have been a hot topic of controversy for a long time. However, recent findings suggest the involving of genetic and chromosomal alterations and the existence of a stress-inducing pathogenetic pathway, in which risk factors such as demographic and environmental ones can converge.

To expand the frontier of knowledge about a malformation that has showed a growing global prevalence, we have conducted a review of the medical literature that gathers information on the embryonic development of the ventral body wall, the primitive intestine, and the ring-umbilical cord complex, as well as on the theories about its origin, pathogenesis and recent epidemiological evidence, for which we consulted bibliographic databases and standard search engines

Keywords : Gastroschisis; abdominal abnormalities; Hernia umbilical; Vitelline duct; ectopia cordis; genetic predisposition to disease.

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