Abstract

BAENA VALENCIA, Juan Camilo; PELAEZ GIRALDO, Ivonne  and  CASTANO MOLINA, Eduardo. P53: THE NEVER-ENDING STORY OF A MULTIFACETED GUARDIAN. Biosalud [online]. 2009, vol.8, n.1, pp.217-230. ISSN 1657-9550.

The p53 gene has been extensively studied in recent years, with initial results considering it a tumor promoter. However, currently it is not only recognized for being a tumor repressor, but also for playing a leading role in other cellular processes such as maintaining the integrity of the genome, apoptosis, senescence and development, among others. The limits of its scope are still unknown; however, the information obtained has transcended clinical applications and there is probably much more to explore and implement regarding this multifaceted guardian.

Keywords : p53; tumor suppressor gene; genome guardian.

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