Abstract

OSORIO, José Henry. EVALUATION OF FIVE DIFFERENT SCAN FUNCTIONS FOR THE ANALYSIS OF CARNITINE IN HUMAN PLASMA BY TANDEM MASS SPECTROMETRY. Biosalud [online]. 2012, vol.11, n.2, pp.52-58. ISSN 1657-9550.

Abstract: the determination of carnitine levels through electrospray tandem mass spectrometry using human plasma for the detection of alteration in mitochondrial oxidation of fatty acids and organic acidemias, has been described; however improving precision in the method used for such end is desirable. Materials y methods: carnitine in plasma was measured by tandem mass spectrometry using five different methods: derivatized (4 methods) and underivatized (1 method). Results: no significant difference was observed between the five functions evaluated. Conclusion: any of the functions evaluated can be used to determine carnitine in plasma.

Keywords : carnitine; tandem mass spectrometry; analysis.

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