Abstract

JARAMILLO-RODRIGUEZ, Oscar Darío  and  GONZALEZ-CORREA, Clara Helena. PROBIOTICS IN PRIMARY PREVENTION OF ATOPIC DERMATITIS IN INFANTS AT RISK OF SUFFERING IT: METAANALYSIS. Biosalud [online]. 2013, vol.12, n.1, pp.18-28. ISSN 1657-9550.

Background: Several studies have used different protocols to evaluate the effect of probiotics in patients at high risk of suffering atopic dermatitis, producing conflicting results. A meta-analysis of randomized double-blind clinical trials was conducted was to elucidate the effect of its use during pregnancy. Methods: The literature search included the PubMed, ScienceDirect, Proquest, and Ovid databases. The keywords were probiotics ATOPIC DERMATITIS and atopic dermatitis. PROBIOTICS. The outcome variable was the incidence of atopic dermatitis. The Cho and Bero scale was used to assess the methodological quality of the articles. For statistical analysis the RevMan 5.1 software and the Mantel-Haenszel test using fixed and ramdomized models were used. Calculations were performed by using the fixed and random effects models. Heterogeneity was examined using the X² test and publication bias was assessed by using the funnel plot and the Egger's statistical test. Results: Seven studies including 1,237 children were analyzed. It was found that the use of probiotics during pregnancy reduces the risk of atopic dermatitis in infants with an odds ratio of 0.64 and confidence intervals of 95% from 0.5 to 0.82.

Keywords : atopic dermatitis; meta-analysis; probiotics; children; pregnant women.

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