Abstract

WANCJER, Benjamin et al. Effects of Different Grades of Physical Activity in the Presentation of Anathomic and Histologic Changes Related with Renal Aging. Rev. Cienc. Salud [online]. 2003, vol.1, n.2, pp.112-134. ISSN 1692-7273.

Objective: With the purpose of determining anatomical changes of exercise in renal aging. Methodology: we carried out an experimental longitudinal study during 54 weeks. 120 swiss male mice were used, which were divided into three groups depending on their activity: sedentary, normal and active. The exercise was modulated with room space and food acces. three animals were sacrificed per group from the ninth week of age, each nine weeks. All animals with less than 27 weeks of age were considered young animals, and old animals were more than 36 weeks old. all mice and kidneys were weighted, establishing a kidney weight/mouse weight relation. The cortex of each animal´s left kidney was measured. And a histological estudy with classical colorations was carried out. Such cuts were analyzed by 2 pathologist who did not know the purpose of this study; they described glomerular changes and interstitial tubulus, classifying them from null to severe. Glomerular areas, as well as light/arterial wall relation were measured. Results: maximum renal growing was detected 18 weeks later. At the 54 th week, the sedentary mice had less cortical thickness (2288,65 ± 552,75) than the animals of the normal group (2502,7 ± 163,81) and the active group (2609,46 ± 273,28), with n=3 for all groups. The glomerular area was significantly less (p=0,035) in sedentary animals (8657,33 ± 1954,38) compared to the active animals (10318,64 ± 2425,14), but significant differences were not found among the normal animals (9791,52 ± 2211,63) and the other to groups, n=18 for each group. tubular atrophy in old animals was 55,5% in sedentary animals, higher than in normal and active animals, in which it was 44,4%, not significant. Interstitial nephritis was less in normal animals (55,5%) compared to sedentary and active groups (77,7%), not significant. Conclusions: We could conclede that the sedentary life in mice is related with some descripting changes of the renal aging such as cortex decreased, glomerular atrophy and increasing risk to develop interstitial nephritis, although moderate exercise may limit severity of such changes, and intense exercise may increased interstitial nephritis.

Keywords : Exercise; kidney; aging; mouse.

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