Abstract

URIBE-YUNDA, Diego Fernando  and  NAVAS, María-Cristina. Molecular mechanism involved in the mutagenicity induced by Aflatoxin B₁. Rev. Cienc. Salud [online]. 2012, vol.10, n.3, pp.403-419. ISSN 1692-7273.

The aflatoxin B₁ (AFB₁) is a mycotoxin that has been identified as the most potent hepatocarcinogen. The metabolite resulting from detoxification process of AFB₁ in liver, has the ability to react with the genomic DNA, generating AFB₁-DNA adducts; during DNA replication process, this adduct induced the G:C—>T:A transversion. Polymorphism in genes encoding for enzymes involved in the activation and detoxification of AFB₁ and DNA repair enzymes has been associated with the risk of hepatocellular carcinoma (HCC) development. Additionally, in populations of high exposure to aflatoxin and high prevalence of hepatitis B virus (HBV) infection, has been demonstrated a synergism between these two risk factors for the development of HCC.

Keywords : Aflatoxin B₁; Hepatitis B virus; Hepatocellular carcinoma; AFB₁ metabolite; AFB₁- DNA adducts; DNA repair.

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