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Revista Ciencias de la Salud

Print version ISSN 1692-7273On-line version ISSN 2145-4507


REMENIK-ZARAUZ, Vania; DIAZ-VELEZ, Cristian  and  APOLAYA-SEGURA, Moisés. Factors Associated with the Presence of Extended-Spectrum Beta-Lactamase-Producing Pathogens in Urinary Tract Infections in a Private Clinic in Lima, Peru. Rev. Cienc. Salud [online]. 2020, vol.18, n.2, pp.29-39. ISSN 1692-7273.


Urinary tract infections (UTIS) are the second most frequent reason for healthcare visits, and antibiotic resistance among gram-negative bacteria of the Enterobacteriaceae family has increased significantly worldwide. The emergence of microorganisms that produce extended-spectrum beta-lactamase (ESBL) is especially problematic. This study aims to identify factors associated with the presence of UTI caused by ESBL-producing pathogens.

Material and methods:

An analytical cross-sectional study was conducted, and the urine culture database from a private healthcare clinic was analyzed. Factors possibly associated with the appearance of UTIS due to ESBL-producing pathogens were analyzed, including sex, age, number of hospitalizations, and previous UTIS.


A total of 1405 positive urine cultures were studied, 85.48% of which belonged to women. The mean age of the subjects was 39.98 ± 24.51 years, 24.13% of whom were over 60 years old. Of these, 55.56% had been attended on an outpatient basis. Almost half (49.18%) of the cultures tested positive for ESBL-related UTI, 96.58% of which had not presented with a previous UTI. A statistically significant association was found between sex and the development of UTI caused by ESBL-producing microorganisms (p = 0.007), with the male sex having the highest association (prevalence ratio, 1.224; 95% confidence interval: 1.035-1.448). In addition, age, number of previous hospitalizations, and prior intensive care unit admissions also showed associations with UTI development. No association was found with the presence of previous UTIS.


A high frequency of UTIS were ESBL-related, and the factors associated with ESBL-related UTIS were male sex, age >60, and previous hospitalizations.

Keywords : Urinary tract infection; beta-lactamase; antibiotic resistance.

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