Abstract

RINCON, Marcela; RODRIGUEZ, Alejandra; LONDONO, Marta Elena  and  ECHAVARRIA, Alejandro. FABRICACIÓN Y CARACTERIZACIÓN DE UNA MATRIZ TRIDIMENSIONAL DE HIDROXIAPATITA MACROPOROSA PARA APLICACIÓN EN INGENIERÍA DE TEJIDOS ÓSEOS. Rev.EIA.Esc.Ing.Antioq [online]. 2007, n.7, pp.87-95. ISSN 1794-1237.

Bone tissue engineering came up as a new option treatment for different kinds of illness, among them bone diseases. All this development has allowed solving multiple medical problems. The development of a hydroxyapatite scaffold for bone cells culture will be another alternative to attend several diseases that are caused on bones and that usually lead to disabilities in people. In this study synthetic hydroxyapatite was produced by a precipitation route with amonium phosphate (NH₄H₂PO₄) and calcium nitrate (Ca(NO₃)₂*4H₂O) as precursors. Scaffolds were manually molded, and macroporosity was induced with a natural agent, named Zea mays, with a particle size ranging between 350 µm and 600 µm. Microporosity was induced using cellulose with proportions of 4% and 8% (weight/weight). The samples were characterized by compression test, scanning electronic microscopy (SEM), energy dispersive spectroscopy (EDS), and X ray diffraction (XRD). Crystalline hydroxyapatite scaffolds were obtained and they presented an average pore diameter between 300 µm and 500 µm, porosities between 35,85% and 45,61%, densities in the range of 1,48-1,77 g/cm³ and Ca/P ratio of 1,7. The calculated compressive strength for the 4% of microporous block was 1,06 MPa and the elastic modulus was 67,15 MPa; while the 8% microporous blocks showed a strength of 1,08 MPa and an elastic modulus of 54,65 MPa.

Keywords : hydroxyapatite; macroporous scaffolds; tissue engineering; bone.

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