Abstract

LOPEZ-BARRIOS, Ena Patricia et al. Antiplasmodial activity in vitro of secondary metabolites of Solanum nudum from two regions of Colombia. Rev.EIA.Esc.Ing.Antioq [online]. 2018, vol.15, n.30, pp.25-39. ISSN 1794-1237.  https://doi.org/10.24050/reia.v15i30.1033.

Solanum nudum is a plant native to Colombia, is recognized and is used for the treatment of fever associated with malaria, specifically in the Pacífico area of Nariño department. In this research a comparative study of phytochemical production of steroidal compounds of S. nudum from two regions of Colombia and their respective antiplasmodial activity was carried out. The collection of the leaves of S. nudum was conducted in the municipalities of Cocorná (Antioquia) and Tumaco (Nariño) in the months of November 2010 and June 2011. The extraction of steroid metabolites present in the leaves were collected from S. nudum was performed with solvents low, medium and high polarity. The content of steroidal metabolites was determined by high resolution liquid chromatography in reverse phase. The antiplasmodial activity of the extracts was evaluated in 3D7 strain of Plasmodium falciparum and its potential cytotoxicity on the cell line HepG-2. The content of steroidal compounds and antiplasmodial activity was higher on extracts from regions and months where the mean precipitation was influenced due to La Niña phenomenon. The extracts more antiplasmodial effect and cytotoxicity were obtained from Tumaco municipality.

Keywords : Solanum nudum; malaria; Plasmodium falciparum; steroidal metabolites; Cocorná; Tumaco.

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