Abstract

PEREZ-SANCHEZ, AMAURY; RANERO-GONZALEZ, ELIZABETH; PEREZ-SANCHEZ, EDDY J.  and  SEGURA-SILVA, RUTDALI MARIA. Simulation of the L-phenylalanine production process by the fermentative route using SuperPro Designer^® simulator. Rev.EIA.Esc.Ing.Antioq [online]. 2021, vol.18, n.35, pp.220-234.  Epub Nov 02, 2021. ISSN 1794-1237.  https://doi.org/10.24050/reia.v18i35.1417.

L-phenylalanine (L-Phe) is one of the eight essential amino acids for the human body. In this work, the simulation of the L-Phe fermentative production process was carried out using the SuperPro Designer® simulator, in order to know its most important profitability indicators under the current economic conditions in Cuba. A sensitivity study was also accomplished with the objective of knowing from which value of the parameter unit selling price of an L-Phe bottle a positive value begins to be obtained of the indicator Net Present Value (NPV). A gross margin of 70.15%, a unit cost of production of USD $ 66.75 per bottle and a return on investment of 38.92% were obtained. From a value of the unit sale price of the L-Phe bottle of USD $ 115.3 the production plant starts to be profitable. The L-Phe production process can be considered profitable and feasible from the techno-economical point of view, based on the results obtained of NPV (USD $ 14,040,000), Internal Rate of Return (49.14%) and Payback Time (2.57 years).

Keywords : Sensitivity study; L-Phenylalanine; Fermentation, Profitability; Simulation; SuperPro Designer ^®.

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