Resumo

GALLON NAUSA, Julián. Morphological changes and inhibition of the growth of Candida albicans in the presence of solution sulfate of a zinc sulfate of zinc. Nova [online]. 2015, vol.13, n.23, pp.7-15. ISSN 1794-2470.

Objective. Identify isolations of C. albicans, in children from 4 to 12 years, of a population of 189 individuals and to evaluate the above mentioned isolations opposite to three concentrations (3 %, 5 % and 7 %) of Sulfate of Zinc. Methods. There were in use the technologies of the Minimal Inhibitory Concentration (CMI) and Kirby Bauer's technology, according to the parameters of the Clinical Laboratory Standards Institute (CLSI). Results: In CMI's method, with the concentrations of 3 % and 5 % one found a decrease in the forming Units of Colonies (UFC) related to the time (24, 48 and 72 hours) compared with the vine-stock control. As for the concentration of 7 %, they did not present forming units of colonies in any of three observed times. With Kirby Bauer's technology, the concentration of 3 % did not present inhibition of the growth; to the concentrations of 5 % and 7 % one presented a halo of 16 mm and 20 mm respectively. The analysis of Microscopy and Electronic Sweep (MBE), it reveals that the Sulfate of Zinc of 3 % and 5 % they present formation of biopelicula and pseudomicelio, unlike the concentration of 7 % where it was observed lisis cellular in all the fields.

Palavras-chave : Candid albicans; sulfate of zinc; inhibition of the growth; resistance; antifúngicos.

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