Abstract

CASTANEDA, Jeimmy; GOMEZ, Karen; CORRALES, Lucía  and  CORTES, Sebastián. A profile of resistance in bacteria and the mechanisms associated due to the presence of the enzyme NDM-1: a systematic review. Nova [online]. 2016, vol.14, n.25, pp.95-111. ISSN 1794-2470.

In 2008 the NDM-1 enzyme was first reported, the enzyme responsible for the resistance to carbapenems. We conducted a systematic review to determine the resistance profile due to the presence of this enzyme in bacteria. We searched academic articles in principal databases resulting in the selection of 154 articles given our inclusion and exclusion criteria. 617 cases and 13 bacterial genera were reported in our sample. We find 4 resistance mechanisms which are principally resistant to beta-lactams and aminoglycosides. Hence, we have that the presence of the NDM-1 increases the likelihood of having genes that improves the bacteria's resistance dramatically. The presence of the NDM-1 induces mechanisms which impacts the effectiveness of antibiotics and appropriate treatments are difficult to find.

Keywords : NDM-1; metallo-beta-lactamases; bacterial resistance.

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