Abstract

BERMUDEZ F, Antonio José  and  ROBAYO G, Dora Beatriz. Chronic disease surveillance by laboratory: a strategy for metabolic diseases. Nova [online]. 2016, vol.14, n.26, pp.85-93. ISSN 1794-2470.

Objective. propose a strategy for the surveillance by laboratory of chronical and not communicable diseases (CNCD), under the hypothesis that laboratory results for metabolic analytes can be distributed in two populations with different averages. Methods. analytical and retrospective study, with results for metabolic screening for 5241 newborns, collected during the years 2014 and 2015, in four hospitals from Barranquilla, Pereira, Popayan and Neiva by Mass Tandem Spectrometry in a Triple Quadrupole (TQD) system, with the Neobase™ kit for determination of small molecules in blood. Results. 5241 samples were analyzed for 44 acylcarnitines for amino acids and organic acids. For each analyte there was 3 to 5% high values (z-score > 3). The averages for both populations, normal and abnormal, differ to a significant level (p < 0.05). Discussion. Regional studies with models raised globally for the surveillance of CNCD, consider socio-demographic, somatometric and nutrition factors. The clinical laboratory is a source of information, through the monitoring of metabolic indicators. Demonstrated that the results of analysis of a molecule can be grouped and distributed according to an abnormal population whose average is an objective indicator. Conclusions. It is possible to use data from laboratory to monitor variation of an analyte, in order to apply it to the CNCD public health surveillance.

Keywords : Epidemiological Surveillance; Chronic Disease; Metabolism; Health Status Indicators; Primary Prevention.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )