Abstract

ASAD, Antonela Sofía et al. Role of mitochondrial-derived peptide humanin as a therapeutic target in cancer and neurodegeneration. Nova [online]. 2019, vol.17, n.32, pp.9-24. ISSN 1794-2470.

Humanin is a mitochondrial-derived peptide which shows robust protective effects against large series of cytotoxic stimuli in many cell types. This makes it an interesting therapeutic target for many diseases, including cancer and neurodegenerative diseases, among others. Furthermore, this peptide could be used as a biomarker for such diseases. Over the last decade, humanin analogs and peptide mimetics have been developed, which exert highly promising results in preclinical models. Besides, the therapeutic potential of gene therapy vectors that overexpress or silence endogenous humanin is under evaluation. Nonetheless, its possible role in cancer progression and chemoresistance are critical issues to be addressed before translating these therapeutic approaches to the clinic. All these matters will be covered in this review.

Keywords : Humanin; mitochondrial-derived peptide; cancer; neurodegenerative diseases.

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