Abstract

FALLA-ZUNIGA, Luis Felipe et al. Mus musculus: an experimental model for Deiodinase (DIO3) and Transthyretin (TTR) expression during placental development. Entramado [online]. 2021, vol.17, n.1, pp.218-230.  Epub May 05, 2021. ISSN 1900-3803.  https://doi.org/10.18041/1900-3803/entramado.1.6538.

Introduction: Correct functioning of hypothalamic-pituitary-thyroid axis is essential for embryonic-fetal growth and development, as it is involved in tissue differentiation, brain and somatic development, bone maturation and metabolic regulation. Maternal thyroid hormones passage to the fetus through the placenta depends on transmembrane transporters, deiodinase enzymes (DIO2 and DIO3) and carrier proteins (TTR). Objective: Identify DIO3 and TTR expression within placental layers of Mus musculus E10.5, E12.5 and E14.5. Methods: Placental structure, DIO3 and TTR expression were evaluated using histochemistry and immunofluorescence techniques. Results: We found that the three placental layers, labyrinth zone, junctional zone, and decidua were present since E10.5. At E12.5 placental final conformation was observed. DIO3 and TTR were detected in the three stages with a predominance in the labyrinth. Conclusion: DIO3 and TTR are expressed throughout the establishment and maturation of mouse placenta. Mice are a useful tool for studying how thyroid hormones are transported from maternal t° fetal circulation at the placenta.

Keywords : Animal models; iodothyronine deiodinase type iii; placenta; prealbumin; pregnancy; thyroid hormones (MeSH).

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