Resumo

GAVIRIA CALLE, Mónica Marcela; POSADA ARIAS, Silvia  e  MIRA HERNANDEZ, Juliana. Acetogenins, alternative cancer treatment in dogs. Ces. Med. Vet. Zootec. [online]. 2018, vol.13, n.2, pp.157-172. ISSN 1900-9607.  https://doi.org/10.21615/cesmvz.13.2.5.

Cancer is a disease that alter cellular processes, like cell metabolism, activation and deactivation of genes and uncontrolled growth. It is one of the main causes of death in humans, as well as in companion animals, which is why it is increasingly important to seek and develop medicines for the treatment. Some of the drugs that are produced to treat cancer come from plants, such as taxol and vincristine. The necessity to expand the use of natural products to treat this disease, not only in humans but also in companion animals such as dogs, opens the doors to seek biological activity of plants that are commonly used because they present some effect over the disease. This is the case of soursop (Annona muricata), from which secondary metabolites (acetogenins) have been extracted and have presented in vitro greater toxicity in cancer cell lines compared to normal cell lines. Therefore, this review was carried out in order to make an approximation of the uses of these metabolites in cancer, for which a search was carried out in PubMed with different key words and it was concluded that acetogenins comprise a potential source for the development of medicines against cancer.

Palavras-chave : Acetogenins; cancer; canine; ACGs.

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