Abstract

MOSCOSO GAMA BAC, Johanna Marcela; CUADROS LOSADA BAC, Astrid Lorena; RICO RUIZ BAC, Dayana Katherine  and  RODRIGUEZ RODRIGUEZ BAC, Braian Julian. Cystatin C as a gold standard biomarker for the acute kidney disease diagnosis in canines. Ces. Med. Vet. Zootec. [online]. 2021, vol.16, n.2, pp.76-102.  Epub Mar 02, 2022. ISSN 1900-9607.  https://doi.org/10.21615/cesmvz.6439.

Canines with kidney lesions are affected by different processes such as filtration, reabsorption and excretion that alter homeostasis. The measurement of alternative biomarkers has served for the diagnosis and prognosis of kidney damage, which has served the veterinarian, not only for the opportunity in early diagnosis but also for preventive exercise. One of the markers that allows evaluating the glomerular filtration rate (GFR) is the serum concentration of creatinine, since it varies in inverse proportions, on the other hand there is creatinine (Ccr), being a good tool to indicate the commitment of glomerular function, although this is not usually so reliable, due to its high interferences at the time of measurement. For this reason, other biomarkers have been postulated that give an earlier prognosis and that allow timely treatment, among them is cystatin C, which has low interindividual variability, since it does not generate protein junctions, does not have tubular secretion, is not generated tubular reabsorption if there is no protein catabolism. The objective of this review is to present Cystatin C (CisC) as a gold standard biomarker for the diagnosis of acute kidney problems in canines, since in human medicine it has already been established that CisC has a better renal diagnostic and determination value. of GFR than serum creatinine. The characteristics that lead this protein to be an excellent renal biomarker is due to the fact that it has a constant production and plasma concentration in situations of absence of GFR variations. To collect the information used in this review, various sources were used such as: PubMed, Scielo, Journal of Small Animal Practice, National Center for Biotechnology Information, where 50 articles were selected to carry out this research.

Keywords : biomarker; canine; cystatin C; disease; filtration.

        · abstract in Spanish | Portuguese     · text in Spanish     · Spanish ( pdf )