Abstract

HANSFORD, Derek J. MICROFABRICATED NANOCHANNELS: NEW TOOLS FOR MOLECULAR MOTION CONTROL. Rev. ing. biomed. [online]. 2009, vol.3, n.5, pp.95-100. ISSN 1909-9762.

This paper presents a review of work on the fabrication and use of nanochannels in silicon and polymers for the control of molecular transport. The method of Sacrificial Layer Lithography is reviewed and demonstrated for silicon and polymers. A novel technique for the productions of conical nanopores through a polymer membrane is also reviewed. Nanochannels and nanopores have many potential applications for drug delivery, immunoprotection of cell implants, blocking of globular proteins from biosensor surfaces, and diagnostic devices. All of these applications benefit from the more direct interactions of devices with biomolecules.

Keywords : Biomolecular separations; Nanofluidics; Silicon and polymer microfabrication; Therapeutic applications.

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