Resumo

OCHOA, Rodrigo; FLOREZ, Andrés  e  MUSKUS, Carlos. DETECTION IN SILICO OF SECOND USE DRUGS WITH POTENTIAL ANTI-LEISHMANIA ACTIVITY. Rev. ing. biomed. [online]. 2011, vol.5, n.10, pp.10-16. ISSN 1909-9762.

Currently, tropical diseases are a major subject of research in biomedical sciences due to its global impact on vulnerable populations. However, these diseases are normally ignored by pharmaceutical companies due to low profitability potential. For that reason, the search of new therapeutic treatments, that are cost-effective, is essential to fight against tropical parasites as Leishmania spp. In this work, a search and selection of drugs with known protein targets, which were deposited in public databases, was conducted. With these target proteins, a search for orthologs in the Leishmania proteome was carried out in order to identify drugs that could also have anti-leishmanial activity. For this purpose bioinformatics tools were implemented. In addition, in the case that Leishmania proteins have its tridimensional structure reported, docking analysis were simulated to corroborate interaction with the drug. At the end, a selection of 10 drugs was identified and is currently being evaluated in in vitro test.

Palavras-chave : Bioinformatics; Drugs; Leishmaniasis; Molecular Targets; Second use.

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