Resumo

COLORADO, Ana Cristina; AGUDELO, Carlos Andrés  e  MONCADA A., María Elena. ANALYSIS OF BIOMATERIALS FOR SKIN TISSUE ENGINEERING: REVIEW. Rev. ing. biomed. [online]. 2013, vol.7, n.14, pp.11-23. ISSN 1909-9762.

Tissue engineering is a research field that has grown over the last thirty years with different applications in skin, bone, neural tissue and cardiovascular tissue, among others. One of the most studied and promising application relates to the engineering of skin tissue, which has led to important advances in the development of skin substitutes. This work reviews the most used biomaterials for applications in the field of skin tissue engineering. The reviewed literature was classified according to the most used natural or synthetic biomaterials and according to their application as dermal, epidermal, or dermal-epidermal substitutes. At the same time, advantages and disadvantages of their in vivo or clinical implementation were considered. Based on this literature review, the biocompatibility of natural materials is appropriate, as well as their grafting efficiency, but their mechanical strength is low. Synthetic materials, in contrast, show higher mechanical strength and are subject of investigations that seek to improve their biocompatibility and biodegradability. This review also showed that the use of nanomaterials is a very promising research area with excellent prospects for applications in tissue engineering.

Palavras-chave : Biomaterials; Nanomaterials; Scaffolds; Tissue engineering; Skin.

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