Abstract

CASTELLANOS GARZON, Rafael Gustavo; BARRIOS PERALTA, Elkin René; VIDES, Alberto  and  OLARTE, María Francisca. Update on the Understanding and Management of Intoxication by Acetaminophen. Univ. Med. [online]. 2018, vol.59, n.4, pp.43-53. ISSN 0041-9095.  https://doi.org/10.11144/javeriana.umed59-4.acet.

Acetaminophen poisoning is one of the most frequent causes of acute fulminant hepatic failure and one of the main causes of care in emergency services due to drug intoxication. Recent progress has been made in the pathophysiological understanding, diagnosis and treatment of this clinical entity. The mechanisms of oxidative stress and mitochondrial DNA damage explain the damage caused by this intoxication. This review presents aspects related to the epidemiology, pathophysiological mechanisms, diagnosis and treatment of acetaminophen intoxication.

Keywords : drug overdose; acetaminophen; hepatotoxicity.

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