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Universitas Medica
versão impressa ISSN 0041-9095versão On-line ISSN 2011-0839
Resumo
GOMEZ, Camilo et al. Association between the Use of Proton Pump Inhibitors and Cognitive Impairment in Older Adults. Univ. Med. [online]. 2019, vol.60, n.1, pp.19-24. ISSN 0041-9095. https://doi.org/10.11144/javeriana.umed60-1.inhi.
Objective:
The objective was to describe the association between the presence of cognitive impairment and the use of proton pump inhibitors (PPI) in the older adult population in Bogotá, Colombia.
Methods:
We analyzed the SABE Bogotá study. This study included 2,000 people over 60 years, in a cross-sectional sample. The variable of interest was the alteration in the modified Mini-Mental State Examination (MMSE-M). It was related to the use of PPI. This analysis was adjusted for factors such as sex, age, years of schooling and marital status.
Results:
The average age was 71.17±8.05 years, 63.4% were women. We found that 20.7% used PPIs, with an average duration of use of 74.8±93.76 months. 12.6% of older adults had altered MMSE-M, with a higher prevalence in PPI users (25.4% vs. 20.02%; p: 0.049). In the multivariate analysis, an association of adjusted risk increase was found between cognitive impairment and the use of PPIs for ≥24 months (OR: 1.90; CI: 1.11-3.24; p = 0.018).
Conclusions:
This study shows an association of a significant increase in the risk between using PPIs for ≥ 24 months and developing cognitive impairment. More studies are needed to conclude a direct causality relationship.
Palavras-chave : older adults; cognitive impairment; proton pump inhibitors.