SciELO - Scientific Electronic Library Online

 
vol.61 issue1Comparison of the Effectiveness, the Safety, and the Pharmacokinetic of Snakebites Antivenoms: ReviewDifficult Conversations in Medicine: Professionalism and Humanism in the Art of Breaking Bad News author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Universitas Medica

Print version ISSN 0041-9095On-line version ISSN 2011-0839

Abstract

BERNAL FORIGUA, Camila et al. Epigenetic Control of Epithelial-Mesenchymal Transition. Univ. Med. [online]. 2020, vol.61, n.1, pp.52-73. ISSN 0041-9095.  https://doi.org/10.11144/javeriana.umed61-1.epig.

The mesenchymal epithelial transition (MET) process allows a temporary epithelial cell to acquire a mesenchymal phenotype in response to an internal or external stimulus. This process is characterized by the activation and repression of genes involved in different signaling pathways associated with migration, invasion and apoptosis, among others. In this process epigenetics plays a fundamental role. Epigenetics comprises four mechanisms: DNA methylation, covalent modification of histones, non-coding RNAs (RNACs) and chromatin remodeling complexes, which regulate the expression of a gene without altering its sequence. In this topic review, the authors describe the main epigenetic mechanisms involved in the regulation of the expression of genes that are activated and repressed throughout the TEM process.

Keywords : epigenetics repression; epithelial-mesenchymal transition; transcription genetic.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )